Are any excipients in animal ivermectin listed as human allergens or cited in adverse reactions?

1. Allergic reactions to ivermectin are documented in humans — usually linked to the drug or parasite death

Clinical and safety summaries list allergic-type adverse events (pruritus, rash, hives, facial and peripheral edema) after ivermectin use in humans, and large-scale ivermectin programs have recorded such reactions; some are attributed to inflammatory responses when parasites die rather than a classic IgE-mediated allergy to an excipient ^{[4] [2] [5]}.

2. Regulatory authorities warn against using animal ivermectin in people because inactive ingredients differ and are unevaluated

The U.S. FDA and other public health advisories explicitly say animal ivermectin products are not for human use and note that many inactive ingredients in veterinary preparations “aren’t evaluated for use in people” or are present in different quantities — a safety concern rather than a catalogued allergen list ^{[3] [1] [6]}.

3. Reporting focuses on the active drug and clinical syndromes, not named veterinary excipients as allergens

Pharmacovigilance studies and prescribing information focus on ivermectin’s known adverse events (including neurologic and dermatologic reactions) and special syndromes (e.g., encephalopathy with Loa loa infection), but they do not provide systematic lists tying specific excipients found in animal products to documented human allergic reactions in the sources provided ^{[5] [7] [8]}.

4. Guidance and fact checks stress toxicity and concentration differences in veterinary products, not specific excipient allergenicity

Fact-checking and health-advisory pieces emphasize that veterinary formulations may be highly concentrated and include inactive ingredients unsuitable for humans; these warnings are framed as general toxicity and safety risks rather than as evidence that a named veterinary excipient is a common human allergen ^{[1] [9] [10]}.

5. Human ivermectin product information lists allergy warnings but does not single out common veterinary excipients

Human prescribing information and clinical resources instruct patients to report allergies to medicines, dyes, preservatives and animals, and they list allergic adverse events observed with ivermectin treatment; they do not, in the supplied material, identify veterinary excipients specifically implicated as allergens ^{[2] [11] [12]}.

6. What the available sources do not say — gaps you should note

Available sources do not mention specific named excipients from animal ivermectin products that have been proven or widely reported as human allergens in clinical literature or regulatory adverse-event listings in the documents provided (not found in current reporting). The product-characteristics document for one veterinary product lists “excipients” in its composition section, but that file excerpt here does not enumerate or link those excipients to human allergic reactions ^[13].

7. Practical takeaways and competing perspectives

Public-health agencies (FDA and others) and mainstream medical information present a unified caution: do not use veterinary ivermectin in humans because of dosing, concentration and untested inactive ingredients ^{[3] [6]}. Clinical literature and drug labels show allergic reactions can occur with ivermectin therapy in humans, often tied to the drug effect or parasite die-off rather than named veterinary excipients ^{[4] [2]}. The sources do not provide competing, high-quality evidence that specific animal-product excipients are established human allergens; therefore the strongest, evidence-based stance in these documents is precaution against veterinary-product use due to unknown and potentially harmful inactive ingredients and higher concentrations ^{[1] [3]}.

If you want, I can:

• Review a specific veterinary product label/excipients list (you provide the product or full SPC) and compare those ingredients to databases of known human allergens, or
• Summarize adverse-event report databases (e.g., VigiBase or FDA MedWatch) for any reports that explicitly name veterinary excipients as suspected allergens — but I’ll need those data or links because available sources here don’t contain that level of detail.