How many healthcare workers were ultimately terminated for refusing COVID-19 vaccines, and where were impacts concentrated?

Checked on January 15, 2026
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Executive summary

Available reporting shows thousands of healthcare workers lost their jobs over COVID-19 vaccine requirements, but no single source provides a comprehensive national or global tally; specific concentrations of terminations are documented in particular health systems, in at least one Canadian province, and where government or federal rules applied (for example, CMS-covered facilities and state mandates) [1] [2] [3] [4] [5].

1. Documented tallies: isolated tallies, not a single total

Concrete, verifiable counts exist for particular employers and jurisdictions rather than for the sector as a whole—for example, British Columbia’s Ministry of Health reported approximately 2,452 health‑care employees terminated for non‑compliance with the provincial vaccination order (BC reporting summarized by CityNews) [1], Houston Methodist reported roughly 150 employees resigned or were fired after refusing vaccination (NPR) [2], and reporting cited in academic and trade coverage mentions large single‑employer actions such as "Mayo Clinic fires 700" in media accounts summarized in the literature [3]; the sources do not add up to a definitive national or global total and frequently treat these figures as employer‑ or jurisdiction‑specific [1] [2] [3].

2. Where impacts were concentrated: jurisdictions, large health systems, and long‑term care

Impacts clustered in places that implemented broad, enforced mandates or where high‑profile employers applied strict compliance policies—provincial orders in B.C. produced thousands of terminations across acute care and long‑term care settings [1], individual U.S. health systems (Houston Methodist and large systems like Mayo as reported in media and summarized in academic outlets) reported hundreds or dozens of departures each [2] [3], and mandates tied to federal funding (CMS rules) and to state requirements meant the brunt fell on employees of facilities participating in Medicare/Medicaid or in states that adopted healthcare worker mandates (CMS rule effects and state mandate overview) [5] [4].

3. Policy context that shaped where terminations happened

Federal and state regulatory decisions shaped the geography of dismissals: the Supreme Court blocked OSHA’s broad employer mandate but left in place CMS‑linked vaccination requirements for many healthcare facilities, concentrating consequences on institutions receiving federal payments; Ballotpedia documents that 15 states issued healthcare worker vaccine requirements between 2021 and 2022, steering where institutional policies had legal backing and where noncompliance could translate into termination [5] [4].

4. Who was most affected within healthcare and why

Settings where mandates were easiest to enforce (acute care, long‑term care, and other regulated professions) saw the most terminations because employers could tie compliance to licensure, facility rules, or federal program participation; reporting on B.C. singles out regulated healthcare roles and long‑term care, while surveys and reviews show vaccine hesitancy varied by occupation, race and workplace pressure—factors that influenced who remained unvaccinated and therefore who faced discipline or dismissal [1] [6] [7] [8].

5. What the reporting does not allow: no comprehensive sectorwide sum

None of the provided sources attempt or claim a comprehensive national or global count of terminated healthcare workers resulting from vaccine refusal, and the public reporting is fragmented across provinces, states, and employers; therefore any single "ultimate" number would require aggregating disparate employer and government records that the cited reporting does not provide [1] [2] [3] [4].

6. Alternative interpretations and implicit agendas in coverage

Different outlets emphasize different narratives—some highlight staffing losses and operational strain when reporting large employer firings (media accounts summarized in academic pieces), others stress high overall uptake among healthcare workers and relatively small refusal rates in many surveys (survey findings showing >90% uptake in some samples), which reflects implicit agendas: labor and political stakeholders emphasize job loss and resistance, public‑health and academic sources underline uptake and the rationale for mandates; both perspectives are present across the sources [6] [7] [3] [2].

Want to dive deeper?
What is the total number of healthcare worker terminations for vaccine refusal reported by U.S. state health departments and major hospital systems combined?
How did CMS’s vaccine rule and its enforcement change staffing and patient care in Medicare/Medicaid‑participating facilities?
Which demographic or occupational groups among healthcare workers had the highest rates of vaccine refusal and were therefore most affected by mandates?