How long does it take a human to recover from a 1325 mg does of ivermectin for horses

1. What “1,325 mg” means against human dosing standards

Typical approved human ivermectin regimens are weight‑based microgram doses — roughly 150–200 µg/kg per dose, with each tablet commonly containing 3 mg — meaning ordinary therapeutic human doses are in the single‑digit milligram range per dose, so a 1,325 mg exposure is orders of magnitude higher than routine human doses ^{[1] [4]}.

2. How the body clears ivermectin and what that implies about timing

Published summaries and dosing calculators report an ivermectin elimination half‑life on the order of tens of hours (one source cites roughly 18 hours), implying plasma levels fall substantially over several days (about 3–4 half‑lives to reach low percentages), so pharmacokinetics predict a large excess dose would drop into lower ranges over days but not instantly, and symptomatic resolution may lag behind plasma decline ^[5].

3. Evidence from animal overdoses: neurologic signs and variable recovery

Equine and other veterinary overdose reports show progressive neurologic signs that often peak within the first 24–72 hours and may worsen before improving; in one three‑horse case clinical signs progressed for about 36 hours, and in a miniature pony treated for overdose there was no neurologic improvement by 71 hours after exposure, requiring interventions and illustrating that severe signs can persist beyond two to three days ^{[6] [3] [7]}.

4. Human reports and poison‑center patterns: symptom types and care needs

Human poison‑center series during the COVID‑19 period documented neurologic symptoms in older adults and linked veterinary formulations and large or repeated dosing to toxicity; reported manifestations include dizziness, ataxia, seizures and coma in serious cases, and clinical management has been supportive because there is no specific antidote widely endorsed — recovery therefore depends on the severity of neurotoxicity and supportive interventions ^{[2] [8] [9]}.

5. What can be inferred about “how long to recover” from a 1,325 mg horse dose

Direct data tying exactly 1,325 mg in humans to a recovery timeline are not available in the supplied literature, but extrapolating from pharmacokinetics and animal/human toxicity reports: plasma ivermectin would be expected to decline substantially over several days (multiple half‑lives), mild symptoms might resolve within days, while significant neurologic toxicity has been reported to persist for several days to more than a week and in rare cases longer, making “recovery” highly case‑dependent and contingent on clinical course and supportive care ^{[5] [3] [2]}.

6. Conflicting context, caveats and agendas in public discussion

Public discussion has been distorted by advocacy for unapproved uses and by anecdotes of self‑medication with veterinary paste; several science and medical outlets emphasize that veterinary formulations are concentrated, can lead to overdoses when given to people, and that claims minimizing risk or touting quick reversibility are sometimes based on incomplete or non‑peer‑reviewed sources ^{[10] [11] [8]}. The supplied non‑clinical calculator that promises rapid, predictable decline and “reversible” symptoms reflects a more reassuring tone than toxicology case series, so it must be balanced against poison‑center and veterinary reports showing prolonged neurotoxicity in some patients and animals ^{[5] [2] [6]}.

7. Bottom line for clinicians and observers

With the evidence available, a human exposed to a roughly 1,325 mg “horse” dose cannot be assigned a precise, universally applicable recovery interval from the supplied sources — pharmacokinetics predict major decline over several days but clinical recovery, especially from neurologic toxicity, can extend from days to weeks and requires supportive medical care; the literature underscores variability and the absence of a single, documented human time course for that exact dose ^{[5] [3] [2]}.