90...12mg tablets of ivermectin...do I take 1 a day til gone?
Executive summary
A blanket instruction to take one 12 mg ivermectin tablet daily until a 90‑tablet supply is finished is not medically sound: ivermectin dosing is weight‑ and indication‑specific, usually given as a single weight‑based dose or short course for parasitic diseases, taken on an empty stomach, and should be prescribed and supervised by a clinician [1] [2] [3] [4]. There are isolated small trials that explored multi‑day dosing for COVID‑19, but larger and authoritative guidance do not support routine daily use and raise safety and efficacy concerns [5] [6].
1. What the bottle doesn’t tell: ivermectin dosing is not “one tablet fits all”
Ivermectin tablets come in different strengths (common regulatory labeling cites 3 mg tablets but 12 mg formulations are marketed in some regions), and the clinically accepted oral dose for approved parasitic infections is calculated by body weight — typically about 150–200 micrograms per kilogram as a single dose, not a fixed daily tablet for an arbitrary period [1] [3] [2]. That means whether 12 mg is one dose, multiple doses, or an overdose depends entirely on the person’s weight and the condition being treated — clinicians use weight‑based tables to translate mcg/kg into tablets [1] [3].
2. Typical regimens: single doses and occasional repeats, not continuous 90‑day courses
For conditions for which ivermectin is approved (for example strongyloidiasis and onchocerciasis), the tablet is usually taken as a single dose on an empty stomach with water; repeat dosing schedules—if needed—are measured in months, not days, and depend on the infection being treated and clinical follow‑up [4] [7] [2]. Some dermatologic/parasitic situations (like crusted scabies or immune suppression) may require two or more doses spaced by one to two weeks or periodic suppressive therapy, but standard practice is not “one tablet every day until the pack is gone” [7] [2].
3. The COVID story: small trials, mixed results, and major trials that found no benefit
A small randomized trial reported earlier viral clearance with 12 mg once daily for five days versus placebo in hospitalized patients, but it was limited in size and context (12 mg daily x5 in that study) [5]. Larger outpatient trials and evidence syntheses have not demonstrated that ivermectin reduces hospitalization or clinically meaningful COVID‑19 outcomes, and major trial results cited by guideline bodies do not support routine off‑label multi‑day use for COVID‑19 [6]. Laboratory studies showing antiviral activity in vitro do not translate directly into safe, effective human dosing [8] [4].
4. Safety, interactions and practical cautions: why unsupervised daily use is risky
Ivermectin is a prescription medicine with side effects and drug interactions; it is metabolized in the liver and can interact with agents that affect P‑glycoprotein, altering ivermectin levels and risk of toxicity, which is why clinicians monitor or adjust dosing in some contexts [9] [7]. Reported side effects include dizziness, headache, gastrointestinal upset and—in rare but serious cases—neurologic events; certain parasitic co‑infections (for example Loa loa) can provoke severe reactions when treated [10] [11]. Labels and prescribing information recommend taking tablets on an empty stomach and following a prescriber’s precise schedule rather than self‑directed long courses [3] [7] [4].
5. Clear bottom line: do not take one 12 mg tablet daily until the pack is finished
A 90‑tablet supply of 12 mg tablets implies a large, inappropriate cumulative dose unless a clinician has explicitly prescribed such a regimen for a specific indication with monitoring; standard, evidence‑based ivermectin use is weight‑based and usually single or short intermittent dosing with clinical follow‑up [1] [4] [7]. If the 90 tablets were prescribed, the prescribing instructions on the label and the prescriber’s rationale should guide use; if the tablets were obtained without a prescription or instructions, medical advice should be sought before taking any. Sources used in this report do not support unsupervised daily dosing until a bottle is finished and document both the standard weight‑based dosing and the safety/monitoring considerations that make “one a day til gone” inappropriate [1] [3] [9] [6].