Which manufacturers supply hydrogen generators and oral hydrogen products used in clinical trials and what corporate ties to study authors are disclosed?
Executive summary
Clinical trials of molecular hydrogen have relied on a small but growing roster of commercial suppliers: makers of hydrogen generators and bottled/tablized oral products such as Hydrogen Water Tablets, HoHo Biotech capsules, The Hydrogen Innovation Company’s HtoEAU, and device firms like H2 Medical Technologies or distributors represented by H2Medical — with broader industrial hydrogen-generator makers listed in trade directories also cited as suppliers or sources of equipment [1][2][3][4][5][6]. Disclosures about corporate ties in the published literature are mixed: some academic reviews and papers explicitly declare no conflicts, while manufacturer websites and press pieces highlight inventor–company links and trial sponsorships that suggest commercial involvement but are not always accompanied by independent conflict-of-interest statements in trial reports [7][1][3][4].
1. Who supplies the oral hydrogen products cited in trials — tablets, capsules and infused waters
Oral hydrogen modalities in human studies have included hydrogen-rich water produced by generators or bottled products and orally administered hydrogen capsules or tablets, with named commercial contributors appearing in the literature such as Hydrogen Water Tablets (tablet delivery system touted by its inventor Alex Tarnava) and HoHo Biotech (porous coral capsules), while reviews also reference proprietary hydrogen‑infused beverages such as HtoEAU tested in randomized trials [1][2][3]. Academic reviews and systematic summaries list multiple oral formats used in clinical work — hydrogen-rich water at set volumes, solid oral hydrogen capsules, and engineered particles like silicon nanoparticles — and note that some companies claim high dissolved-H2 concentrations or specialized carriers used in trials [8][9][10].
2. Who supplies the hydrogen generators used for inhalation or water enrichment in trials
Clinical inhalation studies and device-based trials have relied on specialized hydrogen generator manufacturers and medical-device startups; trade directories enumerate established industrial manufacturers of hydrogen generators (Element 1, Millennium Reign Energy and others) and industry-focused firms are now marketing medical water‑enrichment or inhalation systems for research use [6]. Dedicated hydrogen-medical companies such as H2 Medical Technologies / H2 Global Group have announced prototypes and device platforms intended specifically for Alzheimer's and other clinical trials, while distributors and retailers like H2Medical curate consumer and clinical-grade hydrogen water enrichment generators from multiple manufacturers [4][5].
3. What corporate ties to study authors are disclosed in the peer‑reviewed literature
Disclosure practices in the hydrogen field are heterogeneous: an American Journal of the Medical Sciences review summarized funding sources for registered hydrogen trials and reported that most trials were government‑funded (9 of 12), with a minority funded by private-for-profit entities, and the review’s author declared no conflict of interest — indicating public funding predominates in many registries while private sponsorship exists and is disclosed when present [7]. Individual clinical trials vary: some published trials identify the specific product or device used (e.g., HYDRO2EAU trials led by Professor Sergej M. Ostojic reported by The Hydrogen Innovation Company), but the primary public materials from manufacturers emphasize their own research collaborations and product backing rather than always reproducing full academic conflict‑of‑interest statements on corporate pages [3][1]. Reviews and methodology papers sometimes note author declarations of no competing interests, yet many company-promoted claims about product use in trials are presented on corporate sites and industry press without the full transparency of peer‑reviewed conflict disclosures [7][3][1].
4. How to read these ties: transparency, marketing and scientific context
The record shows both responsible academic practices — government funding and explicit no‑conflict declarations in some reviews — and a parallel commercial ecosystem that markets tablets, capsules and devices and profiles inventors or founders who also appear in the research narrative (e.g., inventor–entrepreneur claims from Hydrogen Water Tablets and promotional framing from H2 Global Group), creating potential for promotional bias even when formal conflicts are absent from trial manuscripts [7][1][4]. Independent systematic reviews point to many preclinical and clinical publications but also flag heterogeneity in delivery, dosing and reporting, which amplifies the need to scrutinize funding and author declarations case by case rather than assuming uniform independence [8][11].
5. Bottom line for investigators and clinicians
Reported suppliers in the literature and industry include niche medical hydrogen companies (H2 Medical Technologies, The Hydrogen Innovation Company), consumer/clinical device vendors (H2Medical, KYK brands), capsule and tablet manufacturers (Hydrogen Water Tablets, HoHo Biotech), and broader hydrogen-generator manufacturers listed in trade directories; disclosures range from formal no‑conflict statements in some academic reviews to promotional manufacturer claims about involvement in trials that require verification within the original trial publications to confirm declared author ties and funding [6][5][1][2][3][7].