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How does the cost of semaglutide cyanocobalamin compare to Ozempic and Mounjaro for weight loss?

Checked on November 6, 2025
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Executive Summary

Semaglutide cyanocobalamin is presented in available analyses as a lower-cost, compounded alternative to branded semaglutide (Ozempic) and tirzepatide (Mounjaro), with listed price points substantially below typical branded costs; the main cost driver across sources is the semaglutide component, not the added vitamin B12. The available materials emphasize that compounded semaglutide formulations are not manufactured or approved by the drug makers (Novo Nordisk) and that direct, apples-to-apples comparisons with Ozempic and Mounjaro are limited or absent in the provided data [1] [2] [3].

1. What sellers are actually claiming — clear price contrasts that catch attention

Commercial listings and guides included in the dataset present concrete price references for semaglutide cyanocobalamin and compounded semaglutide, framing them as affordable alternatives to branded injectables. One source lists semaglutide cyanocobalamin at $33.75 per injection with four injections per vial, explicitly positioning the product as more economical than branded counterparts while noting its compounded status and lack of association with Novo Nordisk [2]. Another vendor lists a one-month supply at $290 and a separate listing at $320, reinforcing a narrative of substantially lower cash prices for compounded preparations compared with typical retail costs for branded GLP-1 drugs [3]. The pricing messages are unambiguous: compounded semaglutide products are marketed on cost savings, with B12 addition presented as a minor cost factor [1] [3].

2. The industry caveat: regulatory and provenance signals you must not ignore

All analyses underline that semaglutide cyanocobalamin products in these listings are compounded and not FDA-approved branded formulations, a crucial distinction that affects safety, quality assurance, and legal positioning. The dataset notes explicitly that these compounded products are not associated with Novo Nordisk and that neither the manufacturer nor the FDA has evaluated their effectiveness or safety in the same way as branded drugs [2]. The pricing advantage is therefore coupled with tradeoffs: compounding introduces variability, and oversight differs from that governing commercial pharmaceuticals. Sellers and guides stress clinician supervision for use, signaling both a risk-management posture and an attempt to legitimize compounded availability despite regulatory and manufacturer non-affiliation [2] [1].

3. Cost composition: why B12 barely moves the needle on price

The analyses converge on the economic point that the semaglutide molecule is the dominant price driver, and adding cyanocobalamin (vitamin B12) to the preparation does not materially increase the overall cost per treatment. One guide concludes that B12 addition is a minor cost element compared with the semaglutide itself and recommends that patients explore various coverage and payment scenarios to manage budgets, implying that formulation changes have limited impact on total outlay [1]. Vendor listings mirror this, offering bundled compounded products at single monthly or per-injection prices that suggest the cyanocobalamin component is a low-cost adjunct rather than a price determinant [3] [2].

4. Missing apples-to-apples comparisons — what the dataset does not provide

The provided materials fail to deliver a direct, contemporaneous comparison of standard retail or insured out-of-pocket prices for Ozempic and Mounjaro alongside the compounded semaglutide cyanocobalamin listings. The guide acknowledges this limitation and recommends further research into insurance coverage, cash pricing, and compounding variations to reach an informed conclusion [1]. Vendor pages list their own prices but do not juxtapose those figures against current branded retail prices or efficacy/safety data for comparative value assessments. This omission leaves unresolved questions about total cost of care, including manufacturer coupons, insurance copays, and dosing differences between medications [1] [3].

5. Practical takeaway: cost savings exist but come with tradeoffs buyers must weigh

From the assembled analyses, the clear fact is that compounded semaglutide cyanocobalamin appears materially cheaper on listed cash-price metrics in the dataset, with per-injection and monthly figures substantially below typical expectations for branded GLP-1 therapies [2] [3]. Those savings are paired with explicit caveats: compounded status, lack of manufacturer/FDA equivalence, and clinician-supervision recommendations, all of which signal potential quality, safety, and legal tradeoffs that patients and clinicians must evaluate. The dataset’s own advisory is to explore multiple sourcing, insurance scenarios, and clinician guidance before concluding that lower upfront cost is the best value for a given patient [1].

Want to dive deeper?
How much does semaglutide cyanocobalamin cost per month in 2025?
Is semaglutide cyanocobalamin FDA-approved for weight loss or compounded only?
How do Ozempic (semaglutide) and Mounjaro (tirzepatide) list prices compare for equivalent weight-loss dosing?
Can insurance or manufacturer coupons significantly reduce out-of-pocket cost for Ozempic or Mounjaro in 2024–2025?
What are safety and regulation differences between compounded semaglutide cyanocobalamin and brand-name Ozempic or Mounjaro?