Are there registered clinical trials (ClinicalTrials.gov or WHO ICTRP) testing Sidr honey for any health outcomes?
Executive summary
A focused review of the materials provided finds no evidence in the supplied reporting that any clinical trials of Sidr (Ziziphus) honey are registered on ClinicalTrials.gov or the WHO International Clinical Trials Registry Platform (ICTRP) search portal; the literature cited instead documents in vitro and animal studies and notes a shortage of controlled human trials [1] [2] [3] [4] [5]. The registries and search tools exist and are the correct places to look for formal trial registration, but the reporting emphasizes that most Sidr honey work remains preclinical or small, uncontrolled human studies rather than prospectively registered clinical trials [6] [7] [5].
1. The registries that would show a Sidr honey clinical trial exist and are searchable
ClinicalTrials.gov is the largest public registry of trials and is maintained by the U.S. National Library of Medicine; the WHO ICTRP provides a search portal that aggregates trial records from ClinicalTrials.gov and many national registries to provide a single point of access [1] [2] [6]. The ICTRP explicitly warns that it is a portal—not a place to register trials—and offers search guidance and filters (for example, “with results only” and prospective-registration flags) to help identify human studies [2] [7]. Methodological guides reinforce that using both ClinicalTrials.gov and the ICTRP is best practice when seeking ongoing or completed trials [8] [9].
2. Published Sidr honey research is mainly laboratory and animal work, not registered human trials
Multiple peer‑reviewed publications summarized in the supplied reporting describe in vitro antimicrobial, antioxidant, immunomodulatory, and anticancer assays of Sidr honey and some animal models showing gastroprotective or tissue-protective effects, but these works are laboratory or animal experiments rather than prospectively registered human clinical trials [3] [4]. Reviews and consumer-facing reporting point out the predominance of in vitro experiments and small human studies, and explicitly list the lack of standardization and the predominance of non-clinical work as a limitation—language that supports the conclusion that rigorously designed, registered human trials are not yet established in the literature provided [5] [4].
3. The supplied reporting does not identify any ClinicalTrials.gov or ICTRP records for Sidr honey
Nowhere among the provided registry guidance pages, search‑tips documents, or the Sidr honey research summaries is there an example or citation of a trial registration record for Sidr (Ziziphus) honey on ClinicalTrials.gov or the ICTRP search portal; the materials instead emphasize how to search those portals and note that many Sidr studies remain preclinical or small and unstandardized [2] [7] [3] [5]. Because ICTRP aggregates ClinicalTrials.gov and other primary registries, a bona fide registered human clinical trial would be expected to appear in one or both sources, and the reporting offers no such record [6] [10].
4. Alternative explanations and caveats drawn from the sources
A plausible reason for the absence of registry records in the supplied reporting is that research on Sidr honey to date has focused on lab and animal models or small clinical observations and has not progressed to trials that meet registration requirements; commentators cited in the sources call for larger, standardized, multicenter clinical trials to establish efficacy in humans [5] [4]. It remains possible—outside the scope of the supplied documents—that a registered trial exists but was not retrieved or cited in these particular sources; the ICTRP and ClinicalTrials.gov are the authoritative places to check directly and the supplied materials include search tips for doing so [7] [8].
5. Bottom line: based on the reporting provided, no registered human clinical trials of Sidr honey were identified
Given that the supplied sources document laboratory and animal studies, discuss methodological limits of existing human work, and provide guidance for searching ClinicalTrials.gov and the ICTRP without showing any Sidr honey trial records, the responsible conclusion from this reporting is that no registered clinical trials of Sidr honey for health outcomes appear in these materials [3] [4] [5] [1] [2]. To move from promising preclinical signals to clinical recommendations, prospectively registered, adequately powered human trials—registered on ClinicalTrials.gov or a WHO primary registry and therefore visible via the ICTRP portal—would be required [7] [9].