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What are the medical conditions that qualify for SSDI?

Checked on November 8, 2025
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Executive Summary

The Social Security Administration (SSA) evaluates disability claims using a list of medical categories in the "Blue Book" and a five-step sequential evaluation; conditions that qualify for SSDI either meet a specific Blue Book listing or are medically equivalent and prevent substantial gainful activity (SGA) for at least 12 months or are terminal [1] [2]. Common qualifying categories include musculoskeletal, neurological, cardiovascular, respiratory, mental, cancer, immune, endocrine, and others, but approval depends on severity, duration, and documented functional limits rather than diagnosis alone [3] [4] [5].

1. Why the Blue Book Matters — Clear categories, not an exhaustive promise

The SSA’s Listing of Impairments — commonly called the Blue Book — organizes qualifying conditions into major body-system categories and supplies specific clinical criteria for each listed impairment; meeting those criteria establishes disability at step three of the sequential evaluation, effectively guaranteeing benefits if all other nonmedical rules (work credits, SGA) are met [1] [6]. The Blue Book covers adults (Part A) and children (Part B) and emphasizes impairments that are expected to last at least 12 months or result in death; many listed impairments reflect permanent or long-term conditions such as end-stage organ disease, major neurological disorders, and advanced cancers [6] [4]. The Blue Book’s structure helps claimants and adjudicators, but it does not list every disabling condition; the SSA allows claims based on medical equivalence or residual functional capacity assessments when the condition is not explicitly listed [2] [7].

2. What commonly appears on approved SSDI claims — patterns in accepted disorders

Administrative data and legal guides show that musculoskeletal and connective tissue disorders are among the most common approvals, often because chronic back pain, degenerative disc disease, and related impairments are widespread and can produce documented functional limits that preclude SGA [5] [3]. Mental disorders — including major depression, bipolar disorder, schizophrenia, and neurocognitive disorders — also account for a large share of SSDI and SSI determinations, particularly when medical records, therapy notes, and testing document marked limitations in concentration, persistence, or social interaction [3] [5]. Neurological diseases such as multiple sclerosis, Parkinson’s disease, epilepsy, and stroke, plus cancers, heart failure, severe respiratory diseases, and immune disorders (HIV, lupus) are explicitly listed and can qualify when the severity and functional impact meet or exceed listing thresholds [3] [8].

3. How SSA decides when a non-listed condition still qualifies — equivalence and functional limits

If a claimant’s condition is not in the Blue Book, SSA evaluates whether the impairment is medically equivalent to a listing or whether the claimant’s residual functional capacity (RFC) precludes all past relevant work and any other work in the national economy; the key question is functional capacity to perform SGA, not diagnosis alone [2] [7]. The five-step sequential evaluation first screens for SGA, then for severity, then for a Listed impairment or equivalent, then for ability to do past relevant work, and finally for ability to do other work given age, education, and RFC. This process allows conditions not enumerated in the Blue Book to succeed when medical evidence documents comparable limitations, such as debilitating chronic pain or complex multisystem diseases [6] [2].

4. Documentation requirements that make or break a claim — medical proof over labels

SSA requires objective medical evidence, longitudinal records, treatment history, and functional assessments to substantiate severity and duration. For listed disorders the Blue Book often specifies test results, lab values, imaging, or clinical findings; absent a listing, adjudicators rely on consistent medical records, doctors’ opinions, and functional testing to construct an RFC. Claims fail when diagnoses exist but records lack objective measures, when gaps in treatment or noncompliance are unexplained, or when alleged limitations contradict activities of daily living documented in the file [3] [9]. Practically, claimants with common diagnoses like chronic back pain, depression, or COPD must show how those diagnoses translate into work-preclusive limitations through sustained, contemporaneous medical documentation [8] [7].

5. Diverging perspectives and procedural realities — listed clarity vs. real-world barriers

Advocates and legal guides emphasize that the Blue Book provides clarity and a direct path for claimants who match listings, while critics note that many applicants have disabling conditions that fall short of strict listing criteria yet are equally work-preclusive; the SSA’s allowance for equivalence and RFC assessments partially addresses this gap but introduces subjectivity and procedural hurdles [2] [7]. Statistical patterns show musculoskeletal and mental disorders account for many approvals, reflecting both prevalence and the system’s accommodation of functional-limit evidence, but claim delays, denials at initial levels, and high administrative appeal rates demonstrate that diagnosis alone rarely ensures a smooth outcome [5] [9]. Claimants should expect case-specific factual analysis linking medical proof to functional impairment rather than relying solely on diagnostic labels [1] [3].

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