Has Oprah Ever discussed weight-loss drops or similar supplements on her podcast?

1. Oprah moved the conversation from personal diary to medical drugs

Oprah’s long public engagement with weight stretches back decades — she published intimate reflections on weight in a 1993 program segment that later appeared in podcast form ^{[4] [5]}. That personal framing shifted in 2023–2025 into explicit coverage of prescription treatments: a prime‑time ABC special and reporting confirm she discussed weight‑loss medications and helped frame obesity as a medical issue, not merely a personal failing ^{[2] [6]}.

2. Direct podcast episode on Ozempic and GLP‑1s

On January 14, 2025, The Oprah Podcast ran an episode titled “Ozempic & Weight Loss Drugs: How They Work in Your Brain” in which Oprah interviewed Dr. Ania Jastreboff about GLP‑1 medications such as Ozempic, Wegovy, Mounjaro and Zepbound, answering listener questions and sharing patient updates ^[1]. That episode is an explicit, on‑record instance of Oprah discussing these prescription drugs on her podcast ^[1].

3. Oprah has said she used a GLP‑1 agonist herself

Reporting from TODAY and related coverage states that Oprah told The Oprah Podcast she took a GLP‑1 agonist to help lose weight; earlier interviews and her ABC special similarly disclosed her use of prescription weight‑loss medication ^{[3] [2]}. Those sources name the drug class (GLP‑1 agonist/semaglutide family) rather than a single proprietary product in some accounts ^[3].

4. She framed the issue through experts and patient stories

Oprah’s coverage didn’t present pills as a standalone miracle; her ABC special and podcast episodes featured medical experts (Cleveland Clinic, ABC medical correspondents) and patient stories to explain mechanisms, benefits and controversies around the new class of drugs ^{[2] [1]}. The January 2025 podcast included an endocrinologist explaining how GLP‑1s act in the brain and hearing from people who lost significant weight ^[1].

5. Where reporting is consistent and where it varies

Multiple outlets report the same core facts: Oprah has addressed GLP‑1 drugs publicly, she produced a special about weight‑loss drugs, and she said she took a GLP‑1 agonist ^{[3] [2] [1]}. Some secondary or summary pieces add detail about amounts lost or lifestyle context ^{[7] [8]}, but those specifics differ across outlets; the most directly documented podcast episode and ABC special are the most reliable primary references for what she discussed ^{[1] [2]}.

6. What the available sources do not say

Available sources do not mention Oprah promoting over‑the‑counter “weight‑loss drops” or non‑prescription supplements on her podcast. The cited podcast episode and TV special focus on prescription GLP‑1 agonists ^{[1] [2]}. If you are asking about “drops” as a non‑medical supplement category, that claim is not found in current reporting.

7. Why this matters: influence and framing

Oprah’s platform reaches millions; when she moves from personal memoir to expert interviews about prescription drugs, she shapes public perception and demand ^{[2] [1]}. Sources show she used medical voices and patient stories — which broadens context — but they also document her personal disclosure of using a GLP‑1 agonist, a statement that can normalize pharmaceutical options for weight management ^{[3] [2]}.

8. Final takeaways and next steps for verification

If you want the verbatim discussion, listen to The Oprah Podcast episode dated January 14, 2025 and the associated ABC special as primary sources ^{[1] [2]}. For claims about non‑prescription “weight‑loss drops,” the available reporting does not support that Oprah discussed those products on her podcast ^{[1] [2]}.