Were any drug price reductions under Trump measured as percentages and how were they calculated?

Checked on December 1, 2025
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Executive summary

The Trump administration and White House fact sheets have frequently presented drug-price “reductions” as large percentage drops — including claims as high as “500%–1,500%” — but those numbers are mathematically suspect and have been flagged by multiple news outlets and fact-checkers as misleading or impossible [1] [2] [3]. Independent experts and outlets say realistic reductions from proposed policies could plausibly range from about 30%–80% for some drugs under aggressive measures, but procedural limits and the mechanics of “most-favored-nation” (MFN) deals mean these percentages are calculated or framed in different ways by different actors [4] [5].

1. Headline: Two different uses of “percent” — political rhetoric vs. technical estimates

White House releases and President Trump’s public remarks have repeatedly used large, attention‑grabbing percentage language — the President cited reductions “500%, 600%, 700%” and even up to “1,500%” in speeches and interviews [1] [6]. The White House fact sheets describe MFN agreements and claim “substantial” relief without always supplying the precise arithmetic behind headline percentages [7] [8] [9]. News outlets and fact‑checkers treat those political figures as rhetorical, not technical, and point out the mathematical problems in claiming reductions above 100% [2] [3].

2. Headline: Why reductions above 100% are mathematically impossible — how fact‑checkers framed it

AP and Newsweek explain that a price cut greater than 100% would imply a negative price (the drugmaker paying the buyer), so claims of 500%–1,500% reductions are not possible in standard percentage arithmetic [2] [3]. AP reports explicitly labels the “up to 1,500%” claim false and quotes experts calling it “total fiction,” while Newsweek shows the same arithmetic objection and says the remarks signal a misunderstanding of percentages [2] [3].

3. Headline: Where the plausible percentage ranges come from — expert and policy estimates

Independent analysts told PBS that parts of Trump’s policy could plausibly yield price reductions in the “30% to 80%” range for some drugs if MFN and other levers work as intended, but those experts warned the process would not be “almost immediate” and depends on regulatory steps [4]. Trade‑group or legal‑brief summaries and policy analyses describe specific manufacturer deals and program features (for example, advertised discounts “up to 80%” from AstraZeneca in one summary), which are concrete examples of percentage reductions offered by companies under negotiated programs [5].

4. Headline: Different calculations produce different percentages — savings for Medicare vs. list‑price comparisons

The administration sometimes frames savings on government spending (e.g., Medicare’s projected savings if new prices had been in effect) as percentage reductions in spending rather than percentage reductions in unit prices — for example, a news story cites an administration statement that new negotiated prices would have cut Medicare spending on 15 drugs by 44% in a hypothetical year [10]. That 44% is a program‑level spending comparison, not the same as claiming every pill’s price fell by that percentage [10]. Sources do not detail the exact per‑drug arithmetic behind every headline percentage; available sources do not mention a single, uniform calculation method that the White House used for all its percentage claims.

5. Headline: How administration fact sheets and MFN deals present reductions in practice

White House fact sheets describe MFN agreements and list commitments by firms (e.g., Pfizer, AstraZeneca, Lilly, Novo Nordisk) to offer lower prices or MFN prices for Medicaid/Medicare and through TrumpRx channels, and cite these deals as delivering “price relief” without a one‑size‑fits‑all percentage [7] [8] [9]. A legal‑policy roundup (Mintz) and other explainers note company announcements of discounts “up to 80%” for selected programs — those corporate pledges are concrete instances where a percentage is tied to a specific program or product [5].

6. Headline: Competing interpretations and political motives behind big percentages

Independent outlets and fact‑checkers treat the very large percentage claims as political messaging intended to showcase bold action; critics and some conservative groups frame MFN as “price controls” with economic risks [11]. The administration’s fact sheets and Trump’s rhetoric aim to present a narrative of sweeping affordability gains [7] [9], while fact‑checkers and analysts emphasize arithmetic constraints and implementation hurdles [2] [4].

7. Headline: Bottom line — what you can reliably conclude from current reporting

Reliable conclusions in current reporting: the administration and some manufacturers have announced MFN deals and program features that promise lower prices or discounts for certain channels [7] [8] [5]; expert and journalistic analyses show some realistic reductions could be 30%–80% for particular cases but procedural and regulatory realities limit immediacy [4] [5]; claims of reductions above 100% are mathematically impossible and have been debunked by AP and Newsweek [2] [3]. Sources do not provide a single, consistent formula the White House used to generate every percentage headline; available sources do not mention such a unified calculation.

Want to dive deeper?
Which drug price reductions were announced by the Trump administration and what percentage cuts were claimed?
How do you calculate percentage reductions in drug prices versus list price changes or net price changes?
Did Trump-era policies affect out-of-pocket patient costs or only list and negotiated prices?
What data sources and methodologies did watchdogs use to verify reported percentage reductions in drug prices under Trump?
How do percentage reductions under Trump compare with percentage changes under previous and subsequent administrations?