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Fact check: Is age the only factor in terms of a fully developed pre-frontal cortex

Checked on September 13, 2025

1. Summary of the results

The statement that age is the only factor in terms of a fully developed pre-frontal cortex is inaccurate [1]. According to the analyses, the development of a fully mature prefrontal cortex is influenced by a combination of factors, including heredity, environment, prenatal and postnatal insult, nutritional status, sleep patterns, pharmacotherapy, and surgical interventions [1]. While it is generally agreed that the prefrontal cortex usually finishes developing around age 25 [2], this development is not solely determined by age. Neuroscience research informs policy debates about adolescent maturity, but there is a lack of empirical evidence linking neurodevelopmental processes to real-world behavior [3]. The extended development of the prefrontal cortex has implications for risk-taking and emotional regulation in teens, as well as implications for parenting, education, and legal considerations [2].

2. Missing context/alternative viewpoints

Key omitted facts include the role of environmental factors and individual differences in prefrontal cortex development [1]. Additionally, the analyses highlight the importance of situating brain science in the broader context of adolescent developmental science [3]. Alternative viewpoints suggest that brain development should be considered in conjunction with social, emotional, and psychological factors to fully understand adolescent maturity [3]. The following factors are also crucial to consider:

  • Heredity and genetic predisposition [1]
  • Prenatal and postnatal care [1]
  • Nutritional status and sleep patterns [1]
  • Pharmacotherapy and surgical interventions [1]
  • The interplay between brain development and real-world behavior [3]

3. Potential misinformation/bias in the original statement

The original statement may be misleading as it implies that age is the sole determining factor in prefrontal cortex development [1]. This framing may benefit those who advocate for a solely age-based approach to policy and decision-making regarding adolescents, but it neglects the complexity of factors that influence brain development [1]. Furthermore, this statement may oversimplify the relationship between brain development and real-world behavior, which can have implications for policy and practice [3]. The sources suggest that a more nuanced understanding of prefrontal cortex development is necessary, one that takes into account the interplay between biological, environmental, and social factors [1] [3] [2].

Want to dive deeper?
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