Which veterinary ivermectin products list clorsulon or other secondary actives on their labels?
Executive summary
Multiple marketed veterinary ivermectin formulations explicitly list clorsulon as a co‑active on their labels — commonly sold under names like IVOMEC Plus, Ivermax® Plus, Noromectin® Plus, Vetrimec™ Plus and similar generics — and these labels typically specify concentrations of ivermectin 1% w/v and clorsulon 10% w/v and dosing that delivers 10 mg ivermectin and 100 mg clorsulon per mL [1] [2] [3] [4] [5].
1. Products that explicitly pair ivermectin with clorsulon
The clearest, repeatedly documented category are branded “Plus” injections that pair ivermectin with clorsulon: IVOMEC® Plus is labeled as ivermectin plus clorsulon for cattle (1% ivermectin, 10% clorsulon) and is formulated to deliver 200 mcg ivermectin/kg and 2 mg clorsulon/kg at 1 mL/50 kg [1] [6], Ivermax® Plus likewise lists both actives and the same delivered amounts [2] [7], Noromectin® Plus is sold by Norbrook with identical active strengths and dosing guidance [3], and Vetrimec/Vetrimec™ Plus and generics such as VetOne/Vetrimec Plus also list the 1%/10% ivermectin/clorsulon combination on their labels [8] [4].
2. Additional labeled combinations and international equivalents
Beyond the U.S. market brands, international veterinary products similarly combine ivermectin and clorsulon: Virbac’s Virbamec Super (Ivermectin and Clorsulon 10 mg/ml / 100 mg/ml) is registered in European veterinary listings with the same active substance strengths and specified withdrawal periods for meat and offal [5], and manufacturers such as AdvaCare Pharma and other generic suppliers market “Ivermectin + Clorsulon Injection” formulations for veterinary use in global markets [9] [10].
3. What labels list besides the two actives — excipients and formulation details
Product labels routinely also name excipients and formulation solvents: for example, IVOMEC Plus’ label lists glycerol formal (40%) and propylene glycol among formulation components in addition to the ivermectin and clorsulon concentrations [1], and multiple product datasheets emphasize sterile, ready‑to‑use solutions intended for subcutaneous injection with specific needle size and route instructions [1] [3] [2].
4. Why clorsulon is paired with ivermectin and how labels frame that purpose
Manufacturers market the ivermectin–clorsulon pairing to broaden parasiticide coverage — ivermectin provides broad nematode and ectoparasite control while clorsulon is an adult flukicide effective against Fasciola hepatica — and labels explicitly state the combination controls internal and external parasites including adult liver flukes and list the target parasites and duration of protection [6] [3] [4] [5].
5. Regulatory status, approved uses, and label warnings
These combination products are presented as approved veterinary drugs with ANADA or equivalent regulatory citations on some generics, and labels commonly include use restrictions — for example warnings against use in female dairy cattle of breeding age or in unapproved species and specified meat/milk withdrawal periods for food animals [3] [5] [8].
6. Limits of labeling information and safety implications for non‑veterinary use
Labels show the active and excipient content but do not and should not be interpreted as guidance for human use; recent analytical work cautions that veterinary ivermectin products can contain secondary actives and excipients such as clorsulon whose effects in humans are untested and could pose unknown risks, a point underscored by toxicology and residue‑in‑food concerns in the literature [11] [12].
Conclusion
The available product labels and regulatory summaries consistently identify a family of veterinary ivermectin products that explicitly list clorsulon as a secondary active — including IVOMEC Plus, Ivermax Plus, Noromectin Plus, Vetrimec/Vetrimec Plus and international equivalents like Virbamec Super — and those labels also spell out formulation excipients, dosing, restrictions and withdrawal intervals; labels and peer‑reviewed analyses together underline that these combinations are veterinary medicines with specific, licensed uses and documented composition, not substitutes for medically approved human treatments [1] [2] [3] [4] [5] [11].