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Mammalian protein found in Homo sapiens
Ivermectin normally does not cross the human blood–brain barrier (BBB) because P‑glycoprotein (ABCB1/MDR1) at the BBB effluxes the drug; knockout or defective ABCB1 leads to brain levels tens of times...
Oral ivermectin is the standard human route and produces moderate systemic bioavailability that is sensitive to formulation and food (notably high-fat meals) and to intestinal metabolism and efflux me...
Serious neurologic adverse events (encephalopathy, seizures, coma, persistent coma, ataxia) after ivermectin are uncommon but documented, and risk clusters around particular parasitic coinfections (no...
Documented human ivermectin neurotoxicity is uncommon but real: case series and pharmacovigilance reviews describe presentations ranging from confusion, ataxia and tremor to stupor and coma, sometimes...
Ivermectin produces neurotoxicity in humans when it accumulates in the central nervous system — a process normally blocked by P‑glycoprotein — and clinical reports link toxicity to doses well above st...
When patients take multiple prescription drugs, ivermectin dosing is not a one-size-fits-all calculation but a weight-based starting point (typically ~150–200 mcg/kg) that must be reconsidered in ligh...
Ivermectin commonly interacts with drugs that affect CYP3A4 metabolism and P‑glycoprotein (P‑gp) transport, and with substances that add central‑nervous‑system (CNS) depression or alter bleeding risk;...
Controlled human trials and systematic reviews conducted to date do not demonstrate a clear, consistent dose–response increase in adverse events for ivermectin across the common therapeutic range and ...
Ivermectin’s pharmacokinetics are influenced by body composition and age in ways that often affect distribution and timing more than peak systemic exposure, while P‑glycoprotein (P‑gp) activity and CY...
Ivermectin in adults is associated with a spectrum of recognized adverse reactions that can be neurological (confusion, seizures, encephalopathy) and allergic or cutaneous (rash, pruritus, severe hype...
Ivermectin’s standard, evidence-backed human dosing for parasitic infections is generally in the 150–200 micrograms per kilogram (mcg/kg) single-dose range, with some indications and expert guides ext...