Index/Organizations/donanemab

donanemab

Experimental drug for the treatment of Alzheimer's disease

Fact-Checks

6 results
Jan 12, 2026
Most Viewed

Does memo blast heal amyloid plaque

No reliable information about a therapy called "memo blast" is present in the supplied reporting, so its effects cannot be judged from these sources; the documents instead evaluate anti-amyloid monocl...

Jan 15, 2026
Most Viewed

How does APOE‑ε4 carrier status change the management and MRI surveillance schedule for patients on lecanemab or donanemab?

APOE‑ε4 carrier status meaningfully raises the risk of amyloid‑related imaging abnormalities (ARIA) with both lecanemab and donanemab, and that elevated risk has been translated into mandatory APOE ge...

Jan 14, 2026
Most Viewed

How do anti‑amyloid antibodies like lecanemab and donanemab differ in trial design, efficacy and safety outcomes for early AD?

Lecanemab and donanemab are two recently approved anti‑amyloid monoclonal antibodies tested in large, randomized trials in early Alzheimer’s disease that both produced substantial amyloid PET clearanc...

Jan 12, 2026

What are the specific risks and monitoring requirements for patients receiving lecanemab or donanemab?

Two monoclonal antibodies—lecanemab (Leqembi) and donanemab (Kisunla)—offer modest slowing of early Alzheimer’s symptoms but carry specific, sometimes serious safety risks that require structured moni...

Jan 16, 2026

What are the common side effects and monitoring requirements for lecanemab and donanemab?

Lecanemab and donanemab are monoclonal anti‑amyloid antibodies approved for early Alzheimer’s disease that produce modest slowing of decline but carry important and common safety risks—most notably am...

Jan 7, 2026

How clinically meaningful are the cognitive changes seen with lecanemab and donanemab in real‑world patients?

The randomized trials of lecanemab and donanemab showed statistically significant slowing of cognitive and functional decline over 18 months, but the absolute differences were small versus placebo and...