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Species of worm
Ivermectin dosing for human parasitic infections is weight-based, most commonly prescribed at about 200 micrograms per kilogram (mcg/kg) as a single oral dose for strongyloidiasis and many scabies reg...
Ivermectin normally does not cross the human blood–brain barrier (BBB) because P‑glycoprotein (ABCB1/MDR1) at the BBB effluxes the drug; knockout or defective ABCB1 leads to brain levels tens of times...
The CDC recommends including strongyloidiasis, onchocerciasis, and certain soil-transmitted helminths, with dosing and precautions that vary by parasite, patient population, and epidemiologic context....
Serious neurologic adverse events (encephalopathy, seizures, coma, persistent coma, ataxia) after ivermectin are uncommon but documented, and risk clusters around particular parasitic coinfections (no...
Documented human ivermectin neurotoxicity is uncommon but real: case series and pharmacovigilance reviews describe presentations ranging from confusion, ataxia and tremor to stupor and coma, sometimes...
Ivermectin produces neurotoxicity in humans when it accumulates in the central nervous system — a process normally blocked by P‑glycoprotein — and clinical reports link toxicity to doses well above st...
Ivermectin toxicity most commonly arises from overdose, high-dose misuse of veterinary formulations, or situations that let the drug enter the brain — producing neurologic signs (dizziness, ataxia, se...
Ivermectin overdose commonly produces gastrointestinal symptoms (nausea, vomiting, diarrhea), dizziness and other central nervous system effects (drowsiness, headache, tremor), and in more severe case...
Controlled human trials and systematic reviews conducted to date do not demonstrate a clear, consistent dose–response increase in adverse events for ivermectin across the common therapeutic range and ...
Oral ivermectin produces systemic adverse effects that are dose-related and occasionally severe when taken inappropriately or at very high doses, whereas topical formulations confine most effects to l...
Ivermectin in adults is associated with a spectrum of recognized adverse reactions that can be neurological (confusion, seizures, encephalopathy) and allergic or cutaneous (rash, pruritus, severe hype...
Ivermectin’s standard, evidence-backed human dosing for parasitic infections is generally in the 150–200 micrograms per kilogram (mcg/kg) single-dose range, with some indications and expert guides ext...
Serious adverse reactions reported with ivermectin include neurologic events (encephalopathy, confusion, coma), severe cutaneous reactions (Stevens–Johnson syndrome, toxic epidermal necrolysis, DRESS)...
Ivermectin dosing is tailored first to the parasite being treated and the patient’s body weight, with single doses typically in the 150–200 μg/kg range and repeat doses or maintenance schedules determ...
High or non‑prescribed doses of ivermectin have been linked in recent reports and reviews to a spectrum of chiefly neurological and gastrointestinal toxicities — including dizziness, ataxia, tremor, s...