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Look AHEAD Research Group

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Jan 16, 2026

Why does losing weight help with type 2 diabetes?

Losing weight improves type 2 diabetes primarily because it reduces the body’s insulin resistance and hepatic glucose production, restores more normal insulin secretion, and lowers the fat stored in o...

Dec 31, 2025

Which clinical trials support lifestyle‑induced remission of type 2 diabetes (e.g., the DiRECT trial)?

Randomised trials and large cohort studies support that intensive weight-loss–focused lifestyle interventions can induce remission of type 2 diabetes (T2D) for substantial subsets of patients, with th...