factually
Index/Organizations/X-linked adrenal hypoplasia congenita

X-linked adrenal hypoplasia congenita

Adrenal cortical hypofunction that is characterized by a reduction in adrenal gland function resulting from incomplete development of the adrenal cortex and has material basis in the nuclear receptor NR0B1 (DAX1) gene

Fact-Checks

1 result
Jan 22, 2026

What causes have been reported for macrophallia (endocrine, tumors, congenital)?

— clinically noted as an abnormally large penis — has been reported in the literature as arising from three broad groups of causes: endocrine-driven tissue overgrowth (most classically growth‑hormone ...