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Dr. rer. nat. Westfälische Wilhelms-Universität Münster 1970
The Janssen method refers to the original multi-step synthetic route developed by Paul Janssen in the late 1950s–1960s to create fentanyl and its analogs; it proceeds from piperidone precursors throug...
The classical “Janssen” route to fentanyl is a short, high-yield synthetic sequence that constructs the 4-anilidopiperidine core, reduces the piperidone to the corresponding piperidine, installs the N...
Fentanyl was not first created in the United States; it was synthesized and developed by Belgian chemist Paul Janssen at Janssen Pharmaceutica in the late 1950s/early 1960s, where the compound was fir...
Fentanyl was first synthesized and developed by Paul Janssen and patented by his company, Janssen Pharmaceutica; sources describe the compound’s laboratory creation around 1959–1960 and list a formal ...