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2017 meta-analysis

A study examining the link between PDE5 inhibitors and NAION.

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Feb 2, 2026

How do PDE5 inhibitors differ in onset and duration of action and which is best for on‑demand use?

differ primarily in pharmacokinetics—how quickly they reach effective blood levels (onset) and how long they remain active (duration)—and those differences drive which drug is optimal for “on‑demand” ...

Jan 14, 2026

What is the evidence linking PDE5 inhibitors to non‑arteritic anterior ischemic optic neuropathy (NAION)?

The published evidence linking phosphodiesterase‑5 (PDE5) inhibitors (sildenafil, tadalafil, vardenafil) to non‑arteritic anterior ischemic optic neuropathy (NAION) is mixed: epidemiologic meta‑analys...