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5-HTP and L-tryptophan Interactions

5-HTP and L-tryptophan are supplements associated with serotonin-related adverse events and can precipitate serotonin syndrome when combined with SSRIs/SNRIs.

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Jan 10, 2026

What reported cases or pharmacovigilance data exist for serotonin syndrome linked to herbal supplements combined with SSRIs or SNRIs?

Reported evidence that herbal supplements combined with SSRIs or SNRIs can precipitate serotonin syndrome is real but largely anchored in case reports, small case series, perioperative incident report...