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ABCB1 and ivermectin interaction

The ABCB1 gene plays a crucial role in regulating ivermectin's ability to cross the blood-brain barrier, and mutations or inhibition of this gene can increase the risk of neurotoxicity.

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Jan 17, 2026
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What are reported human CSF concentrations of ivermectin in cases of neurotoxicity, and which studies measured them?

Published human reports of ivermectin-associated neurotoxicity document either the drug’s detection in central nervous system tissue or clinical syndromes consistent with CNS penetration, but the revi...

Jan 15, 2026

What are the mechanisms by which ABCB1 (P‑glycoprotein) dysfunction increases ivermectin neurotoxicity risk?

ABCB1 (P‑glycoprotein, P‑gp) functions as a powerful efflux pump at the blood–brain barrier that normally prevents ivermectin accumulation in the CNS, so loss or inhibition of P‑gp permits large incre...