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ABCB1 genetics and CNS drug penetration

The relationship between ABCB1 genetics and central nervous system drug penetration, including the impact of genetic variants on P-glycoprotein expression and function.

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Jan 18, 2026

How do ABCB1/ABCB1 (mdr‑1/P‑gp) genetic variants in humans affect CNS drug penetration and which populations have been screened?

ABCB1 encodes P‑glycoprotein (P‑gp), an efflux pump at the blood–brain barrier that can limit brain concentrations of many drugs; genetic variants in ABCB1 have been shown in vitro and in animal model...