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Adenoviral vector vaccine safety

The safety and potential risks of adenoviral vector vaccines, including the possibility of integration into the human genome and long-term persistence of vaccine vector DNA or proteins.

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Jan 10, 2026

How long do adenoviral vector vaccines typically persist in human tissues in published pharmacokinetic studies?

Published pharmacology and immunology studies show replication-defective adenoviral vector genomes commonly persist at low levels in tissues—most consistently at the injection site (muscle), in liver ...