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Alpha-lipoic acid toxicity

Alpha-lipoic acid is an antioxidant used orally for diabetic neuropathy and other indications, with reported toxic doses clustering around 6g in several cases, resulting in seizures, metabolic collapse, and death in some cases.

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Feb 7, 2026

What are documented case reports of alpha‑lipoic acid toxicity and what doses were involved?

(ALA) is widely used as an over‑the‑counter antioxidant and for , and published clinical toxicology literature documents a very small number of serious intoxications—mostly in children but including r...