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Index/Topics/ALS-PDC on Guam

ALS-PDC on Guam

The neurodegenerative syndrome ALS-PDC on Guam, its symptoms, neuropathology, and potential causes.

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3 results
Jan 18, 2026
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alzheimers parkihsons als in guam

The neurodegenerative syndrome long observed on Guam—called lytico‑bodig or ALS/Parkinsonism‑Dementia Complex (ALS‑PDC)—manifests symptoms that overlap clinically with Alzheimer’s disease, Parkinson’s...

Jan 29, 2026

What evidence exists tying the Guam lytico‑bodig toxin research to specific therapeutic mechanisms or targets?

The body of research points away from a single “toxin→symptom” pathway and toward converging neuropathological signatures—abnormal, prion‑like protein aggregates and tau‑dominated neurofibrillary tang...

Jan 18, 2026

Why did the incidence of ALS/PDC on Guam decline after 1970, according to epidemiological research?

Epidemiological research attributes the sharp decline in Guam’s formerly hyperendemic ALS/PDC after 1970 primarily to changing environmental and lifestyle exposures—most notably a reduction in traditi...

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