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The neurodegenerative syndrome ALS-PDC on Guam, its symptoms, neuropathology, and potential causes.
The neurodegenerative syndrome long observed on Guam—called lytico‑bodig or ALS/Parkinsonism‑Dementia Complex (ALS‑PDC)—manifests symptoms that overlap clinically with Alzheimer’s disease, Parkinson’s...
Epidemiological research attributes the sharp decline in Guam’s formerly hyperendemic ALS/PDC after 1970 primarily to changing environmental and lifestyle exposures—most notably a reduction in traditi...