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Antidiabetics interactions

Potential interactions between antidiabetics and other medications

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Jan 13, 2026
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How do common diabetes medications (metformin, GLP-1 agonists, SGLT2 inhibitors) compare in average A1C reduction and long-term durability?

Metformin, GLP‑1 receptor agonists (GLP‑1RAs) and SGLT2 inhibitors all lower A1C but differ in magnitude and persistence: metformin provides modest, durable reductions and remains first‑line; GLP‑1RAs...