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Index/Topics/Antimalarials

Antimalarials

Some antimalarials can alter ivermectin metabolism

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Feb 2, 2026

What specific drugs most commonly interact with ivermectin via CYP3A4 and how are those interactions managed?

is primarily metabolized by cytochrome P450 3A4 (CYP3A4), so drugs that strongly inhibit or induce CYP3A4 can change ivermectin exposure; in vitro and animal data identify several likely perpetrators,...

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