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Index/Topics/BASE Pilot Trial

BASE Pilot Trial

A pilot trial exploring the safety, tolerability, and pharmacodynamics of bicarbonate in patients with CKD.

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Jan 7, 2026
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What clinical trials have tested sodium bicarbonate supplementation on human endothelial function or flow-mediated dilation?

Two randomized clinical trials directly tested oral sodium bicarbonate for effects on endothelial function measured by brachial artery flow‑mediated dilation (FMD): a small 2018 pilot randomized cross...

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