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Index/Topics/Bupropion and Sexual Dysfunction

Bupropion and Sexual Dysfunction

The relatively lower risk of sexual dysfunction associated with bupropion compared to SSRIs.

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Jan 9, 2026

What are the comparative rates of sexual dysfunction between individual SSRIs, SNRIs, bupropion and mirtazapine in randomized trials?

Randomized trials and pooled analyses consistently show that serotonergic antidepressants — SSRIs and SNRIs — carry substantially higher rates of treatment-emergent sexual dysfunction than non‑seroton...

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