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Index/Topics/Childhood Vaccines Saline Placebo Trials

Childhood Vaccines Saline Placebo Trials

The use of saline placebos in randomized trials for childhood vaccines, including polio, rotavirus, and HPV vaccines.

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Jan 16, 2026

Which childhood vaccines were tested with saline-placebo randomized trials and where can the original trial reports be found?

Multiple childhood vaccines were evaluated in randomized trials that used inert saline placebos—most famously the 1954 Salk polio field trial and several later studies such as rotavirus and at least o...

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