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Index/Topics/CLARITY-AD Trial

CLARITY-AD Trial

CLARITY-AD trial results, including infusion reaction rates for lecanemab

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3 results
Jan 24, 2026

What infrastructure and staffing changes do infusion centers need to safely deliver and monitor anti‑amyloid antibody treatments?

Infusion centers that plan to deliver must expand beyond routine infusion capacity: they need protocols and physical space for repeated IV infusions, rapid access to MRI and laboratory testing for sur...

Jan 12, 2026

How do anti‑amyloid monoclonal antibodies differ in mechanism, efficacy, and safety (lecanemab vs donanemab vs aducanumab)?

Anti‑amyloid monoclonal antibodies differ in what forms of Aβ they bind, how much they lower brain amyloid and downstream biomarkers, and in clinical benefit versus risk balance: lecanemab targets sol...

Jan 7, 2026

How clinically meaningful are the cognitive changes seen with lecanemab and donanemab in real‑world patients?

The randomized trials of lecanemab and donanemab showed statistically significant slowing of cognitive and functional decline over 18 months, but the absolute differences were small versus placebo and...

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