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Index/Topics/Combination Therapies

Combination Therapies

Combination therapies, including the use of multiple medications or higher doses, may be effective for patients who do not respond to monotherapy.

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Jan 16, 2026
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What trials are testing immunotherapy combinations for MSS colorectal cancer and what early results exist?

Microsatellite-stable (MSS) colorectal cancer has largely been refractory to single‑agent immune checkpoint inhibitors, so current clinical research is focused on rational combinations—checkpoint dual...

Jan 19, 2026

What trial designs best test whether prior PDE5 inhibitor response modifies benefit from new ED therapies?

To test whether prior response to PDE5 inhibitors modifies benefit from a new erectile dysfunction (ED) therapy, the most reliable approaches are prospective randomized designs that stratify or random...