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COSMOS trials

The COSMOS trials tested a commercially available multivitamin-mineral formulation within a large, randomized, double-blind, placebo-controlled 2×2 factorial study also testing cocoa flavanols.

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Jan 28, 2026
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What did the COSMOS trials use for multivitamin composition and which populations were studied?

The tested a commercially available multivitamin-mineral (MVM) formulation—reported by the study team as ® (or a formulation very similar to Centrum Silver® Adults 50+)—within a large, randomized, dou...