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CYP3A4 Inhibitors

Drugs that inhibit CYP3A4 can change ivermectin exposure

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4 results
Feb 2, 2026

What specific drugs most commonly interact with ivermectin via CYP3A4 and how are those interactions managed?

is primarily metabolized by cytochrome P450 3A4 (CYP3A4), so drugs that strongly inhibit or induce CYP3A4 can change ivermectin exposure; in vitro and animal data identify several likely perpetrators,...

Jan 28, 2026

Which CYP3A4 inhibitors require dose adjustment or avoidance of specific PDE5 inhibitors?

Potent and moderate —including azole antifungals (ketoconazole, itraconazole), macrolide antibiotics (erythromycin, clarithromycin), (ritonavir, saquinavir, amprenavir, fosamprenavir and others), cert...

Jan 8, 2026

Which commonly prescribed antifungals and antibiotics are strongest CYP3A4 inhibitors and how do they affect drug levels in older adults?

Two classes of commonly prescribed anti-infectives — certain systemic azole antifungals and macrolide antibiotics — are among the strongest clinically relevant inhibitors of cytochrome P450 3A4 (CYP3A...

Jan 8, 2026

Which common medications taken by seniors have clinically significant interactions with repeated-dose ivermectin?

Repeated-dose oral ivermectin can interact with a range of medications commonly taken by older adults, most notably blood thinners such as warfarin, strong CYP3A4 inhibitors (for example ketoconazole ...