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Cytochrome P450 enzymes interaction

Drug-herb interactions via cytochrome P450 enzymes presenting clinically meaningful risks

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Jan 16, 2026
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Which prescription drugs metabolized by CYP3A4 have documented interactions with herbal supplements?

St. John’s wort, grapefruit (juice), and a range of polyphenol-rich herbal supplements have documented, clinically significant interactions with prescription drugs that are substrates of CYP3A4, alter...

Jan 8, 2026

Which commonly prescribed antifungals and antibiotics are strongest CYP3A4 inhibitors and how do they affect drug levels in older adults?

Two classes of commonly prescribed anti-infectives — certain systemic azole antifungals and macrolide antibiotics — are among the strongest clinically relevant inhibitors of cytochrome P450 3A4 (CYP3A...