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Index/Topics/Dementia Risk

Dementia Risk

The potential link between beta-blockers that cross the blood-brain barrier and altered dementia risk.

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Jan 13, 2026

Which beta‑blockers cross the blood–brain barrier and what clinical evidence links them to memory or cognitive changes?

Lipophilicity determines which beta‑blockers cross the blood–brain barrier (BBB): highly lipophilic agents such as propranolol — and to a lesser extent metoprolol and carvedilol — penetrate brain tiss...

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