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Index/Topics/Depression trials

Depression trials

Clinical trials for depression

Fact-Checks

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Jan 10, 2026

How does saffron affect serotonin levels and interact with SSRIs or SNRIs?

Saffron’s active compounds—especially crocin and safranal—appear to increase synaptic serotonin (and other monoamines) by inhibiting reuptake, which gives it antidepressant and anxiolytic potential . ...

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