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DiRECT Trial

A clinical trial that demonstrated the effectiveness of a structured weight-loss program in achieving type 2 diabetes remission.

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6 results
Jan 29, 2026
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What are medically proven strategies for managing or achieving remission of type 2 diabetes?

Medically proven strategies that can manage and in many cases induce remission of (T2DM) center on substantial and sustained weight loss achieved via intensive lifestyle interventions, , short-term in...

Jan 10, 2026
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What proven medical and lifestyle strategies can lead to remission or improved control of type 2 diabetes?

Type 2 diabetes (T2D) can be pushed into remission or markedly better glycemic control by several proven strategies: intensive weight-loss–focused lifestyle programs, metabolic/bariatric surgery, shor...

Feb 1, 2026

What peer‑reviewed clinical trials exist that demonstrate reversal of type 2 diabetes and what interventions produced them?

Randomized and controlled clinical trials show that type 2 diabetes (T2D) remission—sustained non‑diabetic glycemia off glucose‑lowering drugs for defined periods—can be achieved by several interventi...

Jan 31, 2026

What distinguishes diabetes remission from a cure, according to endocrinology guidelines?

Endocrinology guidelines distinguish "" from "cure" for type 2 diabetes by using measurable, time‑bound glycemic criteria and by emphasizing continued surveillance and risk despite normalized blood gl...

Jan 19, 2026

How do remission rates compare between intensive lifestyle programs, GLP‑1 receptor agonist therapy, and bariatric surgery in randomized trials?

Randomized-trial evidence shows that structured intensive lifestyle programs can induce remission of type 2 diabetes in a meaningful minority of participants, GLP‑1 receptor agonists produce larger sh...

Jan 12, 2026

What clinical trials compare behavioral diabetes programs to standard care in improving A1c and diabetes remission rates?

Randomized trials have directly compared intensive behavioral/lifestyle programs to standard medical care and shown meaningful A1c reductions and, in some cases, rates of type 2 diabetes remission—mos...