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DiRECT Trial

Landmark randomized program showing nurse-led, primary-care intensive lifestyle and low-energy diets producing diabetes remission

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Jan 19, 2026

How do remission rates compare between intensive lifestyle programs, GLP‑1 receptor agonist therapy, and bariatric surgery in randomized trials?

Randomized-trial evidence shows that structured intensive lifestyle programs can induce remission of type 2 diabetes in a meaningful minority of participants, GLP‑1 receptor agonists produce larger sh...

Jan 12, 2026

What clinical trials compare behavioral diabetes programs to standard care in improving A1c and diabetes remission rates?

Randomized trials have directly compared intensive behavioral/lifestyle programs to standard medical care and shown meaningful A1c reductions and, in some cases, rates of type 2 diabetes remission—mos...

Jan 10, 2026

What proven medical and lifestyle strategies can lead to remission or improved control of type 2 diabetes?

Type 2 diabetes (T2D) can be pushed into remission or markedly better glycemic control by several proven strategies: intensive weight-loss–focused lifestyle programs, metabolic/bariatric surgery, shor...