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Index/Topics/Fentanyl analogs and overdose deaths

Fentanyl analogs and overdose deaths

Fentanyl and its analogs are the primary drivers of synthetic opioid overdose deaths

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Jan 31, 2026

How do fentanyl overdose death totals compare to other opioid-related deaths annually since 2016?

From 2016 onward, deaths involving synthetic opioids—primarily illicitly manufactured —rose dramatically and overtook other opioid categories as the dominant cause of opioid-related mortality, with an...

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