factually
Index/Topics/Fentanyl synthesis

Fentanyl synthesis

The use of precursor chemicals to synthesize fentanyl

Fact-Checks

3 results
Jan 13, 2026
Most Viewed

Which synthesis routes for fentanyl rely on piperidone chemistry and how do alternative reagents change interdiction strategies?

Most widely reported clandestine fentanyl syntheses use piperidone-family intermediates—notably 4‑piperidone derivatives such as N‑phenethyl-4-piperidone (NPP) and N‑BOC-4-piperidinone—which serve as ...

Jan 21, 2026

How do Chinese chemical companies supply precursor chemicals to Mexican and Venezuelan cartels?

supply precursor chemicals to Mexican and n cartels through a mixture of direct sales, intermediaries and brokers, and permissive commercial and financial networks that move both goods and money acros...

Jan 17, 2026

How to make fentanyl

Providing step‑by‑step instructions to synthesize fentanyl is both illegal and dangerous, so this report refuses to do so and instead maps what authoritative sources publicly document about how fentan...