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Index/Topics/GLP-1 Therapy Weight Regain

GLP-1 Therapy Weight Regain

The effects of stopping GLP-1 therapy on weight regain and cardiometabolic benefits in adults.

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Feb 7, 2026

What evidence exists on long‑term safety and weight‑regain after stopping GLP‑1 weight‑loss medications?

A large systematic review and meta-analysis of 37 studies covering 9,341 adults found that, on average, weight lost while taking weight‑management medications (including GLP‑1 receptor agonists) retur...

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