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Gut Microbiome and Metabolic Signaling

The potential mechanisms by which artificial sweeteners may alter the gut microbiome and influence metabolic signaling pathways.

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Feb 4, 2026

What are the long‑term epidemiological findings on artificial sweeteners (aspartame, acesulfame K) and type 2 diabetes risk?

Long-term prospective epidemiological evidence, most notably from the , finds that higher intakes of —especially aspartame and acesulfame‑K—are associated with an increased risk of incident type 2 dia...