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Index/Topics/Herpes Zoster

Herpes Zoster

A viral infection that causes shingles, with increasing risk and complications in older adults and those with immunocompromising conditions

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Jan 29, 2026
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Absolute risk reduction for shingrix vaccine

-safety">Shingrix’s headline relative efficacy (>90% reduction in shingles cases in trials) masks a much smaller absolute risk reduction (ARR): roughly 3.3–3.6 percentage points over about 3–4 years f...

Jan 31, 2026

How does the number needed to vaccinate (NNV) for Shingrix change by age group and immunocompromise status?

The number needed to vaccinate (NNV) for cannot be pinned to a single figure from available public reports because NNV depends on (VE) and the baseline risk of in the population — parameters that vary...

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