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Index/Topics/Hormone Therapy and Sperm Production

Hormone Therapy and Sperm Production

The effect of hormone therapy on sperm production in transfeminine patients

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Jan 15, 2026

What are typical timelines for sperm production suppression and fertility recovery after starting estrogen and anti-androgens?

Estrogen plus anti-androgens suppress sperm production by shutting down the hypothalamic–pituitary–gonadal axis within weeks, with many patients developing severe oligozoospermia or azoospermia by abo...

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