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Index/Topics/Inflammation and Iron Overload

Inflammation and Iron Overload

Distinguishing inflammation-driven hyperferritinemia from true systemic iron overload

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Jan 26, 2026
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How does inflammation alter ferritin and what tests distinguish inflammation‑driven ferritin elevation from true iron overload?

Inflammation raises serum ferritin as part of the acute‑phase response — cytokines drive iron sequestration in macrophages and increased ferritin synthesis so that ferritin can be high even when body ...

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