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Index/Topics/Ingredient-level studies

Ingredient-level studies

Ingredient-level studies do not substitute for clinical trials of a finished product at the same doses and formulation

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Feb 5, 2026

How do pharmacokinetic exposure‑response analyses differ methodologically from randomized intent‑to‑treat comparisons in drug trials?

(E‑R) analyses and randomized (ITT) comparisons answer different causal questions and use different methodologies: E‑R links individualized drug concentrations to outcomes—often post‑hoc and susceptib...

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