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Index/Topics/Ivermectin and P-glycoprotein Interaction

Ivermectin and P-glycoprotein Interaction

Ivermectin interaction with P-glycoprotein and its effect on chemotherapies

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Jan 17, 2026

Which chemotherapies are most likely to interact pharmacologically with P‑glycoprotein inhibitors like ivermectin?

Ivermectin is both a substrate and inhibitor of P‑glycoprotein (ABCB1/P‑gp), and preclinical work identifies chemotherapies that rely on P‑gp for cellular efflux—most notably taxanes and vinca alkaloi...

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