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Ivermectin Brain Penetration

The relationship between ivermectin brain penetration and genetic variants or drug interactions

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Jan 27, 2026
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Which drug interactions and genetic variants (MDR‑1) increase central nervous system exposure to ivermectin?

Loss-of-function variants in the that abolish (P‑gp) efflux markedly increase , best documented as a 4‑bp deletion in herding‑breed dogs and as rare nonsense mutations in humans . Drugs that inhibit P...

Feb 1, 2026
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What are the clinical signs and timeline of ivermectin overdose in adults and children?

in humans most commonly produces gastrointestinal upset, circulatory instability and a range of neurological symptoms that can progress from lethargy and confusion to seizures, coma and rarely death; ...