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Ivermectin neurotoxicity management and treatment
Laboratory and animal studies report that ivermectin and fenbendazole can kill cancer cells and boost certain chemotherapy effects, but there is no robust human evidence confirming safety or benefit w...
A growing body of clinical and public-health reporting documents that people who ingest ">veterinary ivermectin paste or take very high doses of ivermectin intended for humans can develop acute toxici...
Ivermectin is FDA‑approved for a small set of parasitic indications in humans—oral tablets for certain internal worms and topical formulations for external parasites and some skin conditions—but it is...
shows consistent anticancer activity in cell lines and animal models—blocking pathways like PAK1, Akt/mTOR and Wnt/β‑catenin and inducing apoptosis or autophagy—but this body of evidence remains precl...
Two clinical studies are publicly associated with testing , but only one—the phase I/II trial NCT05318469—has detailed, actively reported design elements: it combines oral ivermectin with an anti‑PD‑1...
Ivermectin can cause common, usually mild adverse effects such as headache, nausea, dizziness, diarrhea, and skin rash when given at approved human doses . Serious but rare harms include neurological ...
There is no single, authoritative global tally of confirmed deaths attributable to ivermectin toxicity; available reporting offers scattered case series and individual reports rather than a comprehens...
Serious neurological events including encephalopathy, altered consciousness and seizures have been reported after ivermectin use, most consistently in persons with high parasite loads or in settings s...
Basal cell carcinoma () is ordinarily treated with procedures and drugs that have robust clinical evidence—surgery (including Mohs), radiotherapy, topical ‑approved agents for superficial lesions, and...
Ivermectin dosing is weight‑based, typically calculated in micrograms per kilogram and most often given as a single oral dose; common regimens for human parasitic infections fall between about 150 and...
Clinical trials and systematic reviews conducted during and after the COVID-19 pandemic provide limited information about ivermectin’s long-term safety in humans; most randomized trials report short f...
High and repeated ivermectin doses explored for oncology have been tested in humans only in limited early-phase or dose‑escalation settings, showing that higher-than-approved regimens can be tolerated...
Published human reports of ivermectin-associated neurotoxicity document either the drug’s detection in central nervous system tissue or clinical syndromes consistent with CNS penetration, but the revi...
Human and veterinary ivermectin products share the same active molecule (a macrocyclic lactone derived from avermectin) but differ sharply in concentration, formulation, excipients and labeling: anima...
No completed human studies specifically reporting the safety or pharmacokinetics (PK) of high‑dose ivermectin in cancer patients have been published in the sources provided; the literature instead con...
A large and disparate body of clinical research tested ivermectin for COVID‑19 using regimens ranging from single low antiparasitic doses (≈150–200 μg/kg) to multi‑day high‑dose courses (including stu...
Loss-of-function variants in the that abolish (P‑gp) efflux markedly increase , best documented as a 4‑bp deletion in herding‑breed dogs and as rare nonsense mutations in humans . Drugs that inhibit P...
Veterinary ivermectin products can contain inactive ingredients and secondary drugs that are untested for human use; the published literature specifically flags clorsulon as a secondary active ingredi...
Ivermectin tablets sold for human use are documented in official product labels and drug information sources as simple, uncoated, white to yellowish‑white tablets whose inactive ingredients are colloi...
A search of the provided reporting finds no definitive randomized controlled trials currently registered testing , or in cancer patients; what does exist are preclinical studies, case‑report compilati...