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The study of how ivermectin is absorbed, distributed, and eliminated in the body
A body of pharmacokinetic studies finds that taking oral ivermectin with food — especially a high‑fat meal — tends to increase systemic exposure (AUC and sometimes Cmax) compared with fasting, but the...
Human-prescription ivermectin is dosed in micrograms per kilogram (commonly 150–200 mcg/kg as a single dose for approved indications), formulated and labeled for oral tablets or topical creams with co...
Standard, single therapeutic oral doses of ivermectin used in humans have not been consistently shown to raise serum creatinine, blood urea nitrogen (BUN), or to reduce glomerular filtration rate (GFR...
Human and veterinary ivermectin often contain the same active molecule, ivermectin, but they differ markedly in formulation type, concentration, approved indications, excipients and regulatory evaluat...
Single oral doses of ivermectin produce a dose-proportional peak plasma concentration (Cmax) with a terminal half-life around 18–20 hours after typical human doses, while repeated or multi-day regimen...
Polyvinylpyrrolidone (PVP) and arabinogalactan (AG) act as formulation excipients that increase ivermectin’s apparent solubility and modify absorption, and mechanochemical complexes containing these e...